Discovery Research Service

Within our Discovery Research Team we collaborate on high-quality basic and translational research with several Scientific Research Centers in European area.

Our scientific teams combine scientific know-how gained from 30 years of experience in the sector and the latest technologies to science in this field. Our famous problem solving oriented team provides the foundation on our Process Development and GMP activities. The Team collaborates actively with TIGEM and its substantial Brain Power in such cases where out of the box solution is required.

Through our Discovery Research Service and also Product Development collaboration we provide fast access to InnovaVector's GMP manufacturing and also our quality and regulatory teams to ensure a ideal product path from research to patients.

Feasibility studies: small scale determination of conditions for best productivity 3,5ml up to 5 ml scale

Vector Design:

Cloning

Molecular Biology:

DNA sequencing and analysis
Gene cloning and subcloning
PCR, RT/qPCR
Vector optimization

Protein Expression Systems:

Mammalian expression in HEK293 and with Client preferred cell line
SDS-PAGE, Western Blotting
AAV Vector Purity Testing by silver staining
LacZ and GFP vectors

Cell Biology:

Full Empty capsid ratio ELISA
Development of functional cell based analyses
Endotoxin Testing

Biodistribution (BD) analysis:

Online AAV tissue search

AVV Production and characterisation

AVV Serotypes

InnovaVector provides AAVs for all common AAV serotypes. The chart below gives a summary of the tropism of AAV serotypes, indicating the optimal serotype(s) for transduction of a given organ.

Virion
* Available shortly
AAV1
AAV2
AAV3
AAV5
AAV6
AAV7
AAV8
AAV9
AAV PHP.B
AAV PHP.eB
AAV rh10
Target Tissue
Muscle, CNS, Heart
Muscle, Liver, Retina, Kidney
Inner ear
Lung, CNS, Retina
Lung (airway), heart, Muscle
Muscle, Liver
Liver, CNS, Heart, Pancreas, Retina, Muscle
Lung, CNS, Heart, Liver, Muscle
CNS
CNS
Brain

Yields from 1 Cellstack-10

Vector
AAV2/1
AAV2/2
AAV2/8
AAV2/9
GC/Cell
1,3E+04
1,5E+04
3,2E+04
3,8E+04
Total GC
1,3E+13
1,5E+13
3,2E+13
3,8E+13

Muscle
Retina
Liver

Download our AAV production Order Form for Preclinical Production service

Download Form

Contact us for more information

Contact us